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Titlebook: Recent Advances in Nervous System Toxicology; Corrado L. Galli,Luigi Manzo,Peter S. Spencer Conference proceedings 1988 Plenum Press, New

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Analysis Of Neurotoxic Disease: The Acrylamide Experienceder is produced? Is it reversible, can it be treated, and what is the prognosis? This paper addresses the orderly analysis of neurotoxic disease, based on experience with a number of human neurotoxins, notably the industrial monomer acrylamide.
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The Nervous System as a Target For Toxic Agentsof cell processes is difficult or impossible. This situation is most characteristic of the nervous system. Mature neurons undergo cell division either rarely or not at all and restoration of complex cell processes interacting with other cell processes may be impossible even if the neuron does not di
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Towards the Molecular Basis of Toxic Neuropathiesrface area nor to provide working materials over such long distances for something like 1500 times its own volume (Table l). Under conditions of normality, the support mechanisms are adequate and enable almost perfect survival during a whole lifetime, and in addition they also allow for occasional r
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Metabolic Activation of Neurotoxicantsis a well established concept in general pharmacology. As the liver is usually the predominant site of biotransformation, tissue damage by metabolites most frequently involves hepatotoxic reactions. Well known examples of drugs converted to hepatotoxic metabolites include paracetamol and isoniazid (
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Mode of Action of Pyrethroid Insecticidesg time. They have, however, never been used on large scale, because they are susceptible to rapid degradation in the environment. Around 1950 several derivatives of the pyrethrins have been synthesized, e.g. allethrin, but these compounds had little advantage over the natural product. It was not unt
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