| 书目名称 | Razoxane and Dexrazoxane - Two Multifunctional Agents | | 副标题 | Experimental and Cli | | 编辑 | Kurt Hellmann,Walter Rhomberg | | 视频video | | | 概述 | Selectively summarizes the >900 publications on these drugs comprehensive overview But cites most papers Shows where lacunae are | | 图书封面 |  | | 描述 | Razoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radiotherapy especially in the treatment of soft tissue sarcomas and gastrointestinal neoplasms.They protect normal tissues against toxic chemicals, e.g. the myocardium against anthracyclines or subcutaneous tissue against injuries caused by incidental extravasations of anthracyclines. Dexrazoxane is the only drug approved by the FDA/EMEA for the specific purpose of preventing cardiac damage when giving the widely used and effective antitumor anthracyclines. The reduction of cardiotoxicity is achieved without response reduction or reducing of time to progression of tumors. While the full analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc.The protection of normal tissues is nowhere | | 出版日期 | Book 2011 | | 关键词 | Radiaton Oncology | | 版次 | 1 | | doi | https://doi.org/10.1007/978-90-481-9168-0 | | isbn_softcover | 978-94-017-8048-3 | | isbn_ebook | 978-90-481-9168-0 | | copyright | Springer Science+Business Media B.V. 2011 |
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发表于 2025-3-21 18:04:08
