Titlebook: Razoxane and Dexrazoxane - Two Multifunctional Agents; Experimental and Cli Kurt Hellmann,Walter Rhomberg Book 2011 Springer Science+Busine

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dermatomyositis

清真寺

豪华

dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radi

尽管

indoctrinate

Introduction,dexrazoxane (ICRF-187) which are the subject of this book. Their history dates back to 1965 and gradually revealed a variety of modes of action which are as unexpected as they are unique – at present. The influence of razoxane and dexrazoxane on the differentiation of a pathologic neovasculature of

Cloudburst

Razoxane,mmarized, e.g. the block of the cell cycle in the G2/M phase, the antimetastatic and antiinvasive activity, the ability to normalize pathological tumor blood vessels, the inhibition of topoisomerase II α, and the metal chelating activity. These activites are associated with a marked radiosensitizati

集聚成团

Dexrazoxane,. Dexrazoxane has two potential pharmacological activities: it is a prodrug that is hydrolyzed to an iron chelating EDTA-type structure, and it is also a strong inhibitor of topoisomerase II. The anthracycline doxorubicin is able to be reductively activated to produce damaging reactive oxygen specie

Headstrong

Summary and Outlook,antiinvasive activity in preclinical experiments, and they are able to normalize pathological tumour blood vessels. In addition, the drugs inhibit topoisomerase II α (the full implications have yet to emerge) and they are powerful chelating agents which not only chelate iron, but also a variety of o

Lacunar-Stroke

Introduction,s an impressive cytoprotective activity in mitigating accidental anthracycline extravasation. In retrospect, the history of the two drugs justifies random screening as a valid method for the discovery of novel and effective drugs.