Titlebook: Raynaud’s Phenomenon; A Guide to Pathogene Fredrick M. Wigley,Ariane L. Herrick,Nicholas A. F Book 20151st edition The Editor(s) (if applic

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Other Secondary Causes,ying driving aetiology (secondary RP; SRP). Recognition of SRP (unlike PRP) is of utmost importance as it may progress to irreversible tissue damage and alert the physician to the presence of an underlying serious disease process. RP secondary to connective tissue disease and to trauma has been disc

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Nailfold Capillaroscopy,fected by the phenomenon of Raynaud (RP) its major role lies in pinpointing those patients who will develop systemic sclerosis (SSc) and in reassuring those patients who have (and will continue to have) a primary (idiopathic) RP. This chapter explains what nailfold capillary microscopy is and elabor

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,Non-invasive Methods of Assessing Raynaud’s Phenomenon,cussion includes the use of dynamic tests such as heating or cooling in addition to baseline measurements. Techniques examined include those used clinically and as research techniques: laser Doppler modalities, infrared thermography, Doppler ultrasound, finger systolic pressure measurement and pleth

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,Autoantibodies in Raynaud’s Phenomenon,and vascular function in health and disease. Autoantibodies can help identify patients with RP at risk of developing an associated autoimmune rheumatic disease in which RP can be the presenting symptom, e.g., systemic sclerosis. Recent work has identified autoantibodies that may contribute to the pa

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Systemic Vasospasm,tivity is also the presumed mechanism underlying several common and uncommon disorders such as migraine headaches, preeclampsia, and variant angina. While epidemiologic studies (case reports, case series, and some controlled studies) have linked RP and these conditions, there is yet to be any clearl

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