Titlebook: Raynaud’s Phenomenon; A Guide to Pathogene Fredrick M. Wigley,Ariane L. Herrick,Nicholas A. F Book 20151st edition The Editor(s) (if applic

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,Design and Reporting of Randomised Controlled Trials for Raynaud’s Phenomenon,ported with care. Additional considerations arise in trials of treatments for Raynaud’s phenomenon due to characteristics of the condition. In particular, strong placebo responses, heterogeneity in the patient population and the impact of seasonal effects on patient outcomes must be accounted for. I

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Raynaud Phenomenon in the Pediatric Age,assurance to the child and family that this condition is relatively benign. Identification of a child with secondary RP or at high risk to progression to secondary RP based on history, examination, and investigations is important to allow more careful monitoring and follow-up, with the aim to detect evolving CTD early.

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Angiography,tion of patients with RP require angiography, this is an important minority because large vessel disease amenable to specific treatment may be identified. Failure to diagnose large vessel disease may result in severe digital ischemia or the need for amputation.

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Definition, Nomenclature, and Diagnostic Criteria,ondary RP when an underlying disease is disclosed. This classification satisfies the needs of the physician in practice. Clinical assessment by history and examination is the gold standard for making a diagnosis.

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Nailfold Capillaroscopy, those patients who have (and will continue to have) a primary (idiopathic) RP. This chapter explains what nailfold capillary microscopy is and elaborates on its place in RP. Data on associations with laser, evaluating the flow of the microvasculature, will be hinted at.