Titlebook: Rational Design of Stable Protein Formulations; Theory and Practice John F. Carpenter,Mark C. Manning Book 2002 Springer Science+Business M

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Book 2002r the past few years, our fundamental understanding of how proteins degrade and how stabilizing agents work has made it possible to approach formulation of protein pharmaceuticals from a much more rational point of view...This book describes the current level of understanding of protein instability

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Physical Stabilization of Proteins in Aqueous Solution,at-urations are often accompanied by covalent and non-covalent aggregates that not only can destroy the activity of the drug, but also cause adverse side effects (.; .). Without the ability to stabilize native protein structures, even the most efficacious protein therapeutics will fail to make viable drug products.

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Tsutomu Arakawa,Tiansheng Li,Linda O. Narhiatement of one of the classic problems of psychology - that of acc­ ounting for motivational or intensive aspects of behaviour, as opposed to structural or directional aspects. The term "energetics" was first used in the 1930‘s by Freeman, Duffy and others, following Cannon‘s energy mobilization vie

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Jeffrey D. Meyer,Bert Ho,Mark C. Manningtary techniques variously have been termed ambush or sit-and-wait strategies; more mobile ones have been called cruise searching, widely ranging searching, active foraging or simply foraging. Some species may employ either type, depending on circumstances (Muma 1966; Cloudsley-Thompson 1991). Interm

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