Titlebook: Rational Design of Stable Protein Formulations; Theory and Practice John F. Carpenter,Mark C. Manning Book 2002 Springer Science+Business M

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Effects of Conformation on the Chemical Stability of Pharmaceutically Relevant Polypeptides,on cannot be ignored. A large number of possible chemical reactions have been identified as leading to decomposition of polypeptides (.). However, a select few are of primary concern to pharmaceutical scientists. In particular, hydrolysis and oxidation reactions appear to be the most common source o

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Spray-Drying of Proteins,y delivery. In addition, fine powders of proteins have application in other delivery systems (e.g., implantable pumps). If the correct formulation and spray-drying conditions can be identified, then a product can be obtained with a high yield and having a large fine-particle dose. Spray-drying is th

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Surfactant-Protein Interactions,ly stable, and thus relatively minor perturbing forces can disrupt protein structure, causing loss of biological activity, as well as formation of non-native protein aggregates. Such perturbations are commonly encountered as proteins are produced, stored, transported, and delivered to patients. For

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1078-0467 formulation of protein pharmaceuticals from a much more rational point of view...This book describes the current level of understanding of protein instability and the strategies for stabilizing proteins under a variety of stressful conditions. .978-1-4613-5131-3978-1-4615-0557-0Series ISSN 1078-0467

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Surfactant-Protein Interactions,ilization (.; .), nebulization (.) and spray-drying (.; .; .; .; .; .) proteins can suffer damage to their native conformation. Further, delivery of protein pharmaceuticals to patients may also provoke losses of conformational integrity via unfavorable interactions of proteins with surfaces (e.g., inner walls of catheter tubing or syringes (.)).