Titlebook: Radiolabeled Monoclonal Antibodies for Imaging and Therapy; Suresh C. Srivastava Conference proceedings 1988 Springer Science+Business Med

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Optimization of Mouse IgG Fragmentation Technique in the Selection of Monoclonal Antibodies for Myocse of myosin fragments. Three monoclonal antibodies selected for their high affinity for human ventricular myosin heavy chains (Leger et al., 1985) are chosen for their cross-reactivity (95%) with canine myosin.

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Sensitivity and Efficacy Indices for Oncologic Data Reporting reconcile data from various centers since they report tumor imaging results in a variety of different ways. The most commonly encountered problem is caused by differences in the method of data reporting. One center will describe sensitivity of detection by site of lesion, while another will report

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Experience with Iodine-123 Labeled Antibodiesfour factors is required: an antibody specific to the cancer in question; a radiolabel that is optimal for the imaging system and for the kinetics of antibody uptake; a method of labeling the antibody and quality control so that is is suitable for injection into the patient; and, a gamma camera imag

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Selection of Monoclonal Antibodies with Optimal Biological Functions for Clinical Applicationies conjugated with radioactive isotopes have been used extensively in preliminary investigations to localize tumor in cancer patients (3,4). In addition, there has been a great deal of current interest in the potential applications of these antibodies in the therapy of human cancer.

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Progress in Diagnostic Immunoscintigraphy and First Approach to Radioimmunotherapy of Colon Carcinom however, were performed with poorly characterized antibodies obtained by absorption and elution from tumor cells or crude tumor fractions. Thus, this type of antibodies could not be used for clinical applications.

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