Titlebook: Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery; Gus R. Rosania,Greg M. Thurber Book 2021 Springer Science+Bus

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Quantitative Determination of Intracellular Bond Cleavagey systems, which drives the subcellular localization and processing of therapeutic cargo. With numerous stimuli-responsive drug delivery systems in development, a quantitative measurement of their intracellular processing is of paramount importance. In this chapter, we discuss methods for determinin

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Development and Application of a Single Cell-Level PK-PD Model for ADCsonents (i.e., antibody, linker, and payload). Pharmacokinetic and pharmacodynamic (PK-PD) modeling and simulation is a powerful tool that can help with this process. It provides a rigorous understanding of how each ADC-related component impacts whole-body disposition and pharmacology of ADCs, and fa

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Tracking siRNA–Nanocarrier Assembly and Disassembly Using FRETt guarantee the incorporation of the nucleic acid into nanosized particles, followed by efficient cellular uptake, resistance to the changing physicochemical environment during endolysosomal trafficking and finally the adequate release of its payload in the cytosol of the cell. While the outcome of

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les in transit. Brain fluids (CSF and brain interstitial fluid) are secreted, flow through particular routes and then drain back into the venous system; this fluid turnover aids central homeostasis and also affects CNS drug concentration. Several CNS pathologies involve changes in the barrier layers

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Kyoung Ah Min,Gus R. Rosaniales in transit. Brain fluids (CSF and brain interstitial fluid) are secreted, flow through particular routes and then drain back into the venous system; this fluid turnover aids central homeostasis and also affects CNS drug concentration. Several CNS pathologies involve changes in the barrier layers

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Joe Bentz BBB model cell lines, which also introduces methodologies for plasma membrane preparations. The expression profile of membrane proteins in cultured cells provides helpful information and new insights for assessing such cells, particularly for in vitro BBB model systems.

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Jibin Li,Qing Wang,Ismael J. HidalgoElectron microscopy indicated FUS activated trans-cellular transport, and reversibly affected tight junctions. Transient disruption of the BBB allowed delivery of both small-molecule drugs (Doxorubicin) and large-molecule antibody-based chemotherapeutic (Herceptin). The FUS-induced BBB disruption al