Titlebook: Osteoarthritis; Clinical and Experim J.-Y. Reginster,J.-P. Pelletier,L. Crasborn Book 1999 Springer-Verlag Berlin Heidelberg 1999 Arthritis

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Models for the Study of Cartilage Damage and Repairmainly assumed by synovial fluid imbibition. Chondrocyte metabolism is regulated by soluble factors produced locally by chondrocytes themselves and also by neighboring tissues. Chondrocyte functions are also influenced by the composition of the extracellular environment (O. tension, ionic concentrat

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Animal Models of Osteoarthritistally induced biological process, amenable to scientific investigation, that in one or more respects resembles the disease in humans.” Animal models of osteoarthritis (OA) are useful in studying the evolution of structural changes in joint tissues, determining how various risk factors may initiate o

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Role of Mechanical Factors in the Aetiology, Pathogenesis and Progression of Osteoarthritis mechanical strain are also crucial for the maintenance of healthy articular cartilage, [3], bone mineral [4] and muscle [5]. Paradoxically mechanical factors also play an important role in the development and progression of osteoarthritis.

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Role of Crystal Deposition in the Osteoarthritic Jointhosphate) and calcium pyrophosphate dihydrate (CPPD) is strongly linked to osteoarthritis. The basis of cartilage damage by crystals has been the subject of numerous investigations. The crystals are thought to either initiate the degenerative process or to amplify ongoing degeneration. However, cont

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Direct Visualization of the Cartilagecourse of OA. These potential disease modifying drugs for OA (DMOADs) are being designed to prevent, delay or even reverse OA changes in the joint. Research into DMOADS requires standardized and reproducible outcome measurements that evaluate changes in the joint. Since many of the potential DMOADS

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Radiographic Imaging of Osteoarthritisce narrowing, corresponding to cartilage loss [1, 2]; subchondral sclerosis and osteophyte formation, the joint’s bony response to the increased mechanical load consequent upon cartilage degeneration and loss [3]. The ease of radiography in detecting these characteristic features, together with the