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Titlebook: Osteoarthritis; Clinical and Experim J.-Y. Reginster,J.-P. Pelletier,L. Crasborn Book 1999 Springer-Verlag Berlin Heidelberg 1999 Arthritis

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Evolution and Prognosis of Osteoarthritisittle is known about the natural course of the disease. The technical investigations, nowadays available, do not allow an individualised approach of prognostic factors. The most recent technics, as magnetic resonance imaging [1, 2], bone scintigraphy [2–5] and serum markers of cartilage loss [6] are
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Impact of Osteoarthritis on Quality of Lifeng bone and soft tissues [1]. Osteoarthritis is the most common rheumatic disorder, and the aging of the population will result in a significant increase in its prevalence [2]. In Western population, as much as one third of the adults aged 25 – 75 years have evidence of radiographic OA [2]. Although
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The European Viewpointevalence of OA have used Kellgren and Lawrence’s system of radiographic changes [1], recent studies have used other measurements, such as self-reports of joint pain, and even where Kellgren and Lawrence’s system is used there is still disagreement about how subjects should be classified using that s
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Role of Growth Factors and Cartilage Repairents, inappropriate matrix assembly, or an imbalance of synovial and cartilaginous homeostasis. Probably the joint has only a limited capacity to react to various insults and, in fact, the osteoarthritic lesion does reflect a common endpoint. However, it seems likely that the mediators involved in t
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