书目名称 | Organ Directed Toxicities of Anticancer Drugs | 副标题 | Proceedings of the F | 编辑 | Miles P. Hacker,John S. Lazo,Thomas R. Tritton | 视频video | | 丛书名称 | Developments in Oncology | 图书封面 |  | 描述 | The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif ferentiate between normal and neoplastic cells, little selectivity exists in currently used oncolytic drugs. Consequently, significant toxicity to the patient is expected when systemic cancer chemotherapy is chosen as an appropriate therapeutic in tervention. Much of this toxicity, such as damage to the bone marrow, gastroin testinal tract, or hair follicles, is predictable based upon the fact that anticancer drugs kill actively dividing cells. These types of toxicities, while serious, are usually manageable and reversible and are, therefore, not often considered to be dose limiting. Unfortunately, several of the most important anticancer drugs also damage tissues in which the growth fraction is relatively small. Such toxicities can not be predicted based on the chemical structure of the drugs, are often not detected in preclinical studies, and are encountered frequently for the first time in clinical studies. Further, unlike most of the proliferative-dependent toxicities, the unpre dicted toxicities are usually irreversible | 出版日期 | Conference proceedings 1988 | 关键词 | cancer; cell; chemotherapy; clinical trial; drug; kidney; research; toxicity | 版次 | 1 | doi | https://doi.org/10.1007/978-1-4613-2023-4 | isbn_softcover | 978-1-4612-9205-0 | isbn_ebook | 978-1-4613-2023-4 | copyright | Martinus Nijhoff Publishing, Boston 1988 |
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