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Titlebook: Organ Directed Toxicities of Anticancer Drugs; Proceedings of the F Miles P. Hacker,John S. Lazo,Thomas R. Tritton Conference proceedings 1

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The Irrelevant Toxicities of Anticancer Drugsy the toxic effects of nitrogen mustard in a large number of human subjects. During the same period of time a few patients with lymphoma were treated at New Haven with nitrogen mustard and enjoyed dramatic, although brief, remission in their disease.
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Base Propenals and the Toxicity of Bleomycin with bleomycin and proposed the intermediacy of a diffusible toxic product. Cohen and I (5) found that bacterial killing by bleomycin occurs at concentrations of drug that do not affect DNA synthesis.
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icities can not be predicted based on the chemical structure of the drugs, are often not detected in preclinical studies, and are encountered frequently for the first time in clinical studies. Further, unlike most of the proliferative-dependent toxicities, the unpre­ dicted toxicities are usually irreversible978-1-4612-9205-0978-1-4613-2023-4
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