Titlebook: Optimization in Drug Discovery; Zhengyin Yan,Gary W. Caldwell Book 2004 Humana Press 2004

Conjuction

Zhengyin Yan,Gary W. CaldwellIncludes supplementary material:

Exclaim

Optimization in Drug Discovery978-1-59259-800-7Series ISSN 1557-2153 Series E-ISSN 1940-6053

云状

micronutrients

Proclaim

Absorption Screening Using the PAMPA Approach,s chapter also discusses how PAMPA has relevance in preformulation research. A detailed PAMPA protocol is presented, with step-by-step instructions for a popular version of the assay, using relatively inexpensive and readily obtainable components.

意外

An Enzymatic Microplate Assay for Testing P-Glycoprotein Substrates and Inhibitors,erapamil, vinblastine, and progesterone) in addition to its basal ATPase activity. This assay uses a coupled enzyme system with spectrophotometric detection for measurement on P-gp-containing native membrane vesicles. This assay may be performed on 96- or 384-well microplates and is therefore suitable for high-throughput screenings.

虚度

放大

彻底明白

到婚嫁年龄

In Vitro CYP Induction in Human Hepatocytes, nontransplantable human liver followed by their culture and treatment with new chemical entities and/or known inducers of cytochrome P450. Enzyme induction in cultured human hepatocytes can be assessed by measuring the levels of messenger ribonucleic acid, immunoreactive protein, and/or cytochrome P450 enzyme activity as outlined in this chapter.