Titlebook: Optimization in Drug Discovery; Zhengyin Yan,Gary W. Caldwell Book 2004 Humana Press 2004

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Use of Caco-2 Cell Monolayers to Study Drug Absorption and Metabolism,nd dietary chemicals. The Food and Drug Administration (FDA) recognized the model system as useful in classifying a compound’s absorption characteristics in the Biopharmaceutics Classification System. In addition to its usefulness as an absorption model, the Caco-2 cells are useful for studying the

antecedence

Absorption Screening Using the PAMPA Approach,earliest absorption, distribution, metabolism, and excretion (ADME) primary screening of research compounds. PAMPA’s popularity in the industry has risen rapidly. This chapter focuses on state-of-the-art PAMPA methods. Evidence will be cited demonstrating that as far as predicting passive permeabili

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Capture

In Vitro Permeation Study With Bovine Brain Microvessel Endothelial Cells, lines such as Caco-2, MDCK, MDCKII, and LLC-PK have been used to predict in vivo intestinal absorption of drugs. However, there are no well-characterized cell lines available representing the blood-brain barrier. In this chapter, the authors describe the primary culture of bovine brain microvessel

植物群

amorphous

大笑

Ablation

Isothermal Titration Calorimetry Characterization of Drug-Binding Energetics to Blood Proteins,les. In this chapter, the authors describe the use of isothermal titration calorimetry (ITC) to measure the binding energetics of drugs bound to blood proteins (i.e., human serum albumin [HSA] and α-acid glycoprotein [AGP]). The stoichiometry (.), the association-binding constant (..), and the entha

噱头

Metabolic Stability Assessed by Liver Microsomes and Hepatocytes,c stability assays, the typical test systems are liver microsomes, liver S9, or hepatocytes (plated or suspended), depending on the goal of the assay. To determine the metabolic stability of a new chemical entity, quantification of the drug candidate from incubate supernatants is required and usuall