Titlebook: Oncogenes; An Introduction to t Kathy B. Burck,Edison T. Liu,James W. Larrick Book 1988 Springer-Verlag New York Inc. 1988 Chromosom.DNA.ca

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, and Related Protein Kinases,inases comprise a family of regulatory enzymes involved in the control of cellular growth and differentiation. The family includes members closely related to .: (1) the . oncogenes that are implicated in the translocation characteristic of chronic myelogenous leukemia, (2) receptors for growth facto

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, Family of Oncogenes,oncogene was the first to be directly implicated in human neoplasia. An H-. gene from a bladder carcinoma cell line was isolated and characterized by its ability to transform the murine cell line NIH 3T3..Single-base-pair differences at specific codons distinguish normal pvoto-. genes from their onc

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Additional Oncogenes, previous chapters we described functional groups of these oncogenes. In this chapter we describe several oncogenes that are as yet unclassified or are novel in their apparent mechanisms (Table 11.1). It is anticipated that eventually the function of these genes will be discovered and their role in

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Transgenic Mice: Direct In Vivo Assay for Oncogenes,uman tissue and human cell lines give circumstantial support to the hypothesis. However, until recently it was not possible to test these genes directly in vivo independently of their association with acute retroviruses. The development of methods to introduce genes into the germ lines of mice and o

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Potential Diagnostic Uses of Oncogenes,l cancers. With chronic myelogenous leukemia, for example, the . oncogene is translocated to chromosome 22 in the vicinity of the . gene. A cancer-specific fusion protein qualitatively different from parent cell proteins is thus produced and is an ideal cancer marker. Mutant ras genes have now been

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Kathy B. Burck M.D., Ph.D.,Edison T. Liu M.D.,James W. Larrick M.D., Ph.D.glich und sinnvoll ist. Bezogen auf Innovationen für Material- und Informationsflußprozesse ist die empirische Untersuchung des Methodeneinsatzes und der Rahmenbedingungen an mehrere Problemkreise gebunden.. Die Analyse bestehender Systeme und ihrer Veränderungsmöglichkeiten erfolgt innerhalb eines