Titlebook: Nutrition and Biotechnology in Heart Disease and Cancer; John B. Longenecker,David Kritchevsky,Marc K. Drez Book 1995 The Editor(s) (if ap

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Louis C. Smith,Randy C. Eisensmith,Savio L. C. Wooaken together, GATA1 plays a key role in regulating megakaryocyte differentiation, maturation, and proliferative capacity. As sequencing and proteomic technologies expand, additional . mutations and regulatory mechanisms contributing to human diseases of megakaryocytes and platelets are likely to be revealed.

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Daniel Steinbergstrategy for gene therapy as an anti-gene strategy, but is also a powerful tool for the study of endogenous gene regulation in vivo as well as in vitro. In this review, we focus on the future potential of decoy ODN-based therapy.

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Nutrition and Biotechnology in Heart Disease and Cancer

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resents a powerful tool in basic science, biotechnology and molecular medicine. In this chapter, we will focus on the different approaches followed to design and to deliver artificial zinc finger transcription factors with the final aim of approaching functional genomics, phenotypic engineering and human gene therapy.

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Steven H. Zeiselor future investigations. E2F activity requires heterodimerization of two partners. Either partner can be one of several different transcription factors; E2Fl, E2F2, E2F3, E2F4, or E2F5 can heterodimerize with either DPl or DP2. Cellular promoters whose E2F sites mediate a link between transcription

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Bob G. Sanders,Kimberly Klineponses triggered by the various ILC subsets have been linked to inflammatory diseases such as inflammatory bowel disease, atopic dermatitis and airway hyperresponsiveness. Here, we will review recent progress in determining the transcriptional and developmental programs that control ILC fate decisions.