Titlebook: Nicotine and Related Alkaloids; Absorption, distribu J. W. Gorrod,J. Wahren Book 1993 Springer Science+Business Media Dordrecht 1993 Oxidat

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Kinetics of nicotine and its metabolites in animals,hly water soluble, strongly alkaline liquid with pKa of (-N=, -N <) 3.2 and 8.0, respectively. At physiological pH nicotine exists mainly in the form of the univalent nicotinium ion which appears, rather than the non-ionized base, to be the active form. Nicotine contains a chiral centre and is found

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Sources of inter-individual variability in nicotine pharmacokinetics,though these responses are determined by many factors, to a certain extent the differences may be attributed to variation in the pharmacokinetics of nicotine, the major pharmacologically active component of tobacco.

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Dealing

New methods for probing the disposition of nicotine in humans,eutical agent in the form of nicotine-containing chewing gum or nicotine preparations for transdermal absorption. The importance of nicotine in human physiology is related to its pleasurable effects as well as to its possible role in tobacco-related disorders. It may be assumed that, as with most ph

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The roles of cytochrome P450 in nicotine metabolism,a, 1988). To date, numerous studies have shown that cytochrome P450 is composed of many molecular forms and their expression is regulated by many factors such as drug administration, age, sex and pathophysiological conditions (Ryan and Levin, 1990; Soucek and Gut, 1992; Funae and Imaoka, 1992).

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