Titlebook: New Concepts in Cancer; Metastasis, Oncogene C. Etievant,J. Cros,Y. M. Rustum Textbook 1990Latest edition Macmillan Publishers Limited 1990

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The Rapid Destruction of Cancer Cells in the Microvasculature, example of this is provided by a patient (KT-2; Glaves .., 1988) who although releasing cancer cells at an average rate of 5xlO9 per day into a renal vein from a 10 cm diameter renal cell carcinoma, was free of metastatic disease 70 months after nephrectomy. This is but one example of what I have t

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The Control of Cell Movement by Laminin, and its Role in Metastasis,vement (Vlodavsky and Gospodarowicz, 1981; Situ ., 1984; Goodman and Newgreen, 1985; Ocalan ., 1988), growth, differentiation (Manthorpe ., 1983) and shape. Not surprisingly, this molecule has been found implicated in biological situations which imply cell migration, tissue remodeling and phenotype

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Dormant Metastatic Cells: Hypotheses on Mechanisms, Magnitude, Failure and Control,therapeutic approaches. Certain cancers are cured by surgery alone, as they have failed to develop a metastatic phenotype at the time of their resection. Other cancers remain essentially unresponsive to all therapeutic modalities, such as glioblastomas and pancreatic cancers. Between these two extre

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Debrief

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The Bombesin Receptor Complex and Cell Growth: Physiology and Pathology,es, like gastrointestinal tract, brain, spinal cord and lung (Walsh ., 1979; Moody and Pert, 1979; Wharton ., 1978) together with specific cell surface receptors (Moody ., 1978; Jensen ., 1978; Zachary and Rozengurt, 1985). A 27 amino acid homologue of bombesin, gastrin releasing peptide (GRP), was

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Hormonal Effects on Gastrointestinal Cancer Growth,ly in the United States (Silverberg and Lubera, 1988). Treatment of patients with these cancers relies heavily on adequate surgical resection. This is effective only when localized tumor is present. There is no effective systemic treatment for metastatic colon, stomach or pancreatic cancer.