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Titlebook: New Aspects of Storage and Release Mechanisms of Catecholamines; Held at Grosse Ledde Hans-Joachim Schümann (Direktor des Pharmakologisc Co

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Quantal or Graded Secretion of Adrenal Medullary Hormone and Sympathetic Neurotransmitterinitial work was done on the skeletal neuromuscular endplate, but it appears that the postjunctional membrane potential (MP) in essentially all neuro-effector junctions so far investigated shows extensive similarities to that of the endplate. Thus in the absence of nerve impulses there are spontaneo
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Chemical Sympathectomy with 6-Hydroxydopamine This principle has found extensive application in the investigation of the physiology and pharmacology of the sympathetic nervous system [. and ., 1949; ., 1963 (1, 2)]. The surgical denervation is still the method of choice for the denervation of organs such as the nictitating membrane, iris or sa
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Saturation of the Uptake of Noradrenaline as a Determinant of Pharmacological Effectss, the uptake mechanism is characterized by lacking stereospecificity and by being saturable ; however, in spite of the lack of stereospecificity, the rate of uptake of d-noradrenaline is lower than that of the l-isomer when the heart is perfused with a concentration of the amine (200 ng/ml) that ca
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