Titlebook: New Aspects in Hypertension Adrenoceptors; Symposium, November Martin Middeke,Heinrich Holzgreve Conference proceedings 1986 Springer-Verl

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Regulation of the ,-Adrenergic Receptor-Adenylate Cyclase System in Cardiac Membranes,effect, whereas other drugs with different structures cause a comparable effect only in much higher concentrations. Paul Ehrlich [28] introduced the hypothesis that drugs that are effective in small concentrations are bound to a specific membrane protein (receptor). He pronounced the well-known sentence: corpora non agent nisi fixata.

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Frequency Regulation in the Sinoatrial Node: Function of ,,- and ,,-Receptors,, 8]. ..- and ..-adrenoceptors have been identified in the ventricular myocardium by means of binding experiments as well as concentration-response curves for the positive inotropic action of .agonists in the absence and presence of partially selective antagonists [4, 7, 10, 11, 14].

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Adrenoceptor Alterations in Different Tissues in Human and Animal Genetic Hypertension,ic agonists has been described in different organs, and particularly in the blood vessels [1–6]. Moreover, antiadrenergic drugs, and particularly alpha and beta blockers, are effective antihypertensive agents.

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