Titlebook: Neuropsychiatric Systemic Lupus Erythematosus; Pathogenesis, Clinic Shunsei Hirohata Book 2018 Springer International Publishing AG, part o

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Psychiatric Symptoms, committee criteria for neuropsychiatric SLE (NPSLE) in 1999, the psychiatric symptoms include acute confusional state (delirium), anxiety disorder, cognitive dysfunction, mood disorder, and psychosis. Because no diagnostic gold standard exists for primary NPSLE, it is often difficult to distinguish

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Treatment of Neuropsychiatric Systemic Lupus Erythematosus,ophysiologic role. The key drugs used in the treatment of neuropsychiatric systemic lupus erythematosus include corticosteroids and immunosuppressive agents to suppress the underlying inflammatory pathology, antiplatelet and antithrombotic agents in the context of thrombosis mediated by antiphosphol

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Promising Treatment Alternatives,ed on clinical experience. Available data on the use of rituximab in refractory NPSLE come from a large number of case reports and some open-label studies. Two patients with persistently active NPSLE, despite conventional therapy, responded dramatically to rituximab are described in this chapter. Cu

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Epidemiology of Neuropsychiatric Systemic Lupus Erythematosus,psychosis is sometimes a difficult differential diagnosis, but not necessarily an exclusion, of lupus psychosis. CSF IL-6 might be one of the surrogate markers to detect patients with headache, cognitive dysfunction and mood disorders, requiring immunosuppressive therapy.

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