| 书目名称 | Neuropsychiatric Systemic Lupus Erythematosus | | 副标题 | Pathogenesis, Clinic | | 编辑 | Shunsei Hirohata | | 视频video | | | 概述 | Presents a valuable tool for clinicians, who will need to make a correct diagnosis of diffuse NPSLE, especially a differential diagnosis from steroid-induced psychosis.Provides a guide for clinical re | | 图书封面 |  | | 描述 | .Neuropsychiatric manifestation in systemic lupus erythematosus (NPSLE) is one of the most recalcitrant complications of the disease. According to the 1999 ACR nomenclature and case definitions, diffuse psychiatric/neuropsychological syndromes in NPSLE (anxiety disorder, acute confusional state, cognitive dysfunction, mood disorder, psychosis) (diffuse NPSLE) present psychiatric manifestations unlike neurologic syndromes (focal NPSLE) originating from focal CNS lesions, such as cerebrovascular disease, demyelinating syndrome, headache, aseptic meningitis, chorea, seizures and myelopathy. A number of studies have reported that diffuse NPSLE is usually associated with the presence of autoantibodies against neuronal cells in serum as well as in cerebrospinal fluid (CSF). Moreover, IL-6 has been shown to be elevated in CSF of patients with diffuse NPSLE..Recently, it has been demonstrated that the severity of blood-brain barrier damages plays a crucial role in the development of acute confusional state, the severest form of diffuse NPSLE through the accelerated entry of larger amounts of autoantibodies to NMDA receptor subunit NR2 into the CNS. Since the importance of autoantibodies in | | 出版日期 | Book 2018 | | 关键词 | epidemiology; genetics; pathology; cytokines; rheumatology | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-76496-2 | | isbn_softcover | 978-3-030-09503-1 | | isbn_ebook | 978-3-319-76496-2 | | copyright | Springer International Publishing AG, part of Springer Nature 2018 |
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发表于 2025-3-21 17:59:43
