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Titlebook: Neuroprotection Methods and Protocols; Tiziana Borsello Book 2007 Humana Press 2007 Alzheimer.Endoplasmatisches Reticulum.Parkinson.Vivo.g

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The Use of Propidium Iodide to Assess Excitotoxic Neuronal Death in Primary Mixed Cortical Culturesatories are engaged in developing or testing drugs to prevent neuronal loss in a variety of these pathologies. A key to testing such drugs is the use of a fast, reliable, and easily reproducible model of neurodegeneration and neuroprotection. Our laboratory has previously used propidium iodide (PI)
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Model of Acute Injury to Study Neuroprotection,NS to tolerate its own mechanism of self-repair. The dismal result is often a wider spread of damage (part of the inevitable “secondary” or “delayed” degeneration) rather than contribution toward a cure. Ever since the phenomenon of posttraumatic damage spread in the CNS was first recognized, neuros
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,Organotypic Entorhino-Hippocampal Slice Cultures—A Tool to Study the Molecular and Cellular Regulatcol based on organotypic slice cultures of mouse entorhinal cortex and hippocampus that can be employed to study axonal regeneration and collateral sprouting in the central nervous system in vitro. Using pharmacological as well as genetic approaches, axonal regeneration and sprouting can be influenc
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,A Method for Isolating Prosurvival Targets of NF-κB/Rel Transcription Factors,mmed cell death (PCD) triggered by tumor necrosis factor α (TNFα) and several other stimuli. The prosurvival activity of NF-κB is also crucial to lymphopoiesis, neuroprotection, tumorigenesis, and cancer chemoresistance. The characterization of the downstream targets that mediate the prosurvival act
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