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Titlebook: Neuronal Nicotinic Receptors; Francesco Clementi,Diego Fornasari,Cecilia Gotti Book 2000 Springer-Verlag Berlin Heildelberg 2000 Alzheimer

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书目名称Neuronal Nicotinic Receptors
编辑Francesco Clementi,Diego Fornasari,Cecilia Gotti
视频video
概述Includes supplementary material:
丛书名称Handbook of Experimental Pharmacology
图书封面Titlebook: Neuronal Nicotinic Receptors;  Francesco Clementi,Diego Fornasari,Cecilia Gotti Book 2000 Springer-Verlag Berlin Heildelberg 2000 Alzheimer
描述Neuronal nicotinic receptors are key molecules for signal transduction in a number of neuronal pathways. They are widely distributed in the brain and are known to be involved in cognitive tasks, including learning and memory, in smoking addiction and in several brain diseases, such as Alzheimer‘s and Parkinson‘s dementias, schizophrenia, and epilepsy. This book provides a comprehensive review of the field, starting with a historical perspective and dealing with the molecular structure of these receptors, their biophysical and pharmacological properties, their distribution in central and peripheral nervous systems, and their major involvement in brain functions. Particular emphasis is paid to drugs (both new and old) that are useful in the diagnosis and treatment of diseases involving neuronal nicotinic receptors. Finally, the relevance of these receptors in smoking addiction is carefully evaluated, together with future trends and the latest results.
出版日期Book 2000
关键词Alzheimer; Degenerative Diseases; Exploration; Nervous System; Neuroreceptors; Neurorezeptor; Nicotin Rece
版次1
doihttps://doi.org/10.1007/978-3-642-57079-7
isbn_softcover978-3-642-63027-9
isbn_ebook978-3-642-57079-7Series ISSN 0171-2004 Series E-ISSN 1865-0325
issn_series 0171-2004
copyrightSpringer-Verlag Berlin Heildelberg 2000
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https://doi.org/10.1007/978-3-642-57079-7Alzheimer; Degenerative Diseases; Exploration; Nervous System; Neuroreceptors; Neurorezeptor; Nicotin Rece
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The History of the Neuronal Nicotinic Receptorspathetic fibres. For this, they used it as a blocking agent rather than as a stimulating agent. However, they did define its site of action quite precisely, as the following quotation from their paper shows:
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Presynaptic Neuronal Nicotinic Receptors: Pharmacology, Heterogeneity, and Cellular Mechanismss is to modulate, rather than mediate, neurotransmission (ROLE and BERG 1996). The presynaptic localisation of nAChRs is compatible with such a role (WONNACOTT 1997). This chapter aims to summarise the evidence for presynaptic nAChRs and to consider the cellular mechanisms relating to their activation and the implications for synaptic functioning.
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0171-2004 ey are widely distributed in the brain and are known to be involved in cognitive tasks, including learning and memory, in smoking addiction and in several brain diseases, such as Alzheimer‘s and Parkinson‘s dementias, schizophrenia, and epilepsy. This book provides a comprehensive review of the fiel
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