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Titlebook: Neuronal Cell Death; Methods and Protocol Arezu Jahani-Asl Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive licen

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书目名称Neuronal Cell Death
副标题Methods and Protocol
编辑Arezu Jahani-Asl
视频videohttp://file.papertrans.cn/665/664262/664262.mp4
概述Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
丛书名称Methods in Molecular Biology
图书封面Titlebook: Neuronal Cell Death; Methods and Protocol Arezu Jahani-Asl Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive licen
描述.This volume covers comprehensive methods on ways to assess structural and ultrastructural changes in the mitochondria, cytoskeleton, and microglia using state-of-the-art microscopy techniques including super-resolution imaging, electron microscopy, and ultra-high field MRI. The chapters in this book cover topics such as analysis of neurodegeneration in the post-mortem characterization of preclinical animal models, in vivo modeling in cell death in different model systems and brain organoids, single cell clonal analysis using Mosaic Analysis with Double Markers in genetic mouse models, and genome and proteomic methods for analysis of mRNA dynamics and quantitation of targeted peptides. Written in the highly successful .Methods in Molecular Biology. series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls..Cutting-edge and thorough, .Neuronal Cell Death: Methods and Protocols. is a valuable resource for any scientist and researcher interested in learning more about this developing field..
出版日期Book 2022
关键词NMAD; authophagy; Axonal degeneration; calcium signalling; Drosophila
版次1
doihttps://doi.org/10.1007/978-1-0716-2409-8
isbn_softcover978-1-0716-2411-1
isbn_ebook978-1-0716-2409-8Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
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Investigating Microglial Ultrastructural Alterations and Intimate Relationships with Neuronal Stresysiology of neurodegenerative conditions, such as Alzheimer’s disease (AD). The heterogeneity of these cells (e.g., the presence of various subtypes like the disease-associated microglia, microglia associated with neurodegeneration, dark microglia, lipid droplet-accumulating microglia), and their ul
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Performing Single-Cell Clonal Analysis in the Mouse Brain Using Mosaic Analysis with Double Markersach neuron are controlled by genes that encode intrinsic and extrinsic factors. Determining the function of these genes at a high spatiotemporal resolution is a critical step toward understanding brain development and function. Moreover, an increasing number of somatic mutations are being discovered
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Modeling Axonal Degeneration Using Motor Nerve Organoids,nal culture system that mimics damages on nerves and axonal tracts hampered development of effective treatments. Here, we describe a method to model degeneration of motor neuron axons using motor nerve organoids that are formed with human induced pluripotent stem cells. In this protocol, motor neuro
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Direct FACS Isolation of Neural Stem/Progenitor Lineages from the Adult Brain,lling evidence suggests that adult neurogenesis plays an important role in hippocampal memory formation, plasticity, and mood regulation. Understanding the mechanisms that regulate the function of neural stem/progenitor cells within the brain is a critical step for the development of regenerative st
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