Titlebook: Neuronal Cell Death; Methods and Protocol Arezu Jahani-Asl Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive licen

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Spinal Cord Injury in the Mouse Using the Infinite Horizon Spinal Cord Impactor,eate both contusion and compression SCI, with a high degree of reproducibility. The device can also be positioned at different locations along the spinal cord to evaluate how the location of injury may alter neuronal death and functional recovery. A mouse with a successful SCI can experience a perio

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Immuno-MALDI-MS for Accurate Quantitation of Targeted Peptides from Volume-Restricted Samples,sis. An internal standard, in the form of a stable isotope-labeled peptide, is used to ensure reproducible and absolute quantitation. The protocol described here was optimized for the quantitation of AKT1 and AKT2, but we offer instructions on how to adapt the method to target other proteins. The de

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Using Single-Molecule Fluorescence Microscopy to Uncover Neuronal Vulnerability to Protein Damage,ion of disease-specific proteins as toxic misfolded aggregates in some areas of the brain. They lead to the loss of protein homeostasis (proteostasis) that causes neuronal dysfunction and death. A potential therapeutic strategy for NDs is to prevent the accumulation of misfolded proteins by activati

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In Vitro Brain Organoids and Computational Models to Study Cell Death in Brain Diseases,genetic factors and the complexity of the environment of the brain. Current preclinical monolayer culture systems fail to faithfully recapitulate the in vivo complexities of the brain. Organoids are three-dimensional (3D) culture systems that mimic much of the complexities of the brain including cel

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Assessment of Neuronal Cell Death in ,ve been characterized extensively in the nematode. In addition, the availability of a wide arsenal of genetic and molecular tools and methodologies renders . an organism of choice for modeling human neurodegenerative diseases. Indeed, neuronal necrosis can readily be observed and examined in vivo, i

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