Titlebook: Neurodegenerative Diseases; Clinical Aspects, Mo Daniela Galimberti,Elio Scarpini Book 2018Latest edition Springer International Publishing

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Genetics and Epigenetics in the Neurodegenerative Disorders of the Central Nervous System,y an insidious onset during adulthood, after which they progress at different rates, ultimately leading to severe physical disability or death. The symptoms are often common among the different disorders: dementia is not only peculiar of Alzheimer’s disease (AD) or frontotemporal dementia (FTD), but

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,Genetic Complexity of Early-Onset Alzheimer’s Disease,Alzheimer’s disease (AD), the most prevalent form of dementia, is important to manage the challenges of aging populations. So far, genetic analyses of families with autosomal dominant AD, presenting with early-onset dementia (<65 years of age), have found three causal genes: ., ., and .. Genetics is

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,Genetic Risk Factors for Complex Forms of Alzheimer’s Disease,heritance. In fact, these forms of AD result from a combination of genetic and environmental factors, with the estimated heritability ranging from 58 to 79%. This chapter reviews the large body of research on genetic risk factors in AD. Linkage analyses and candidate gene association studies have no

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,Risk Factors and Prevention in Alzheimer’s Disease and Dementia,nces at both individual and societal levels. Since so far no effective curative drugs have been found, the identification of modifiable factors to reduce the risk of cognitive decline remains a public health priority. Up to one-third of AD cases worldwide can be attributable to the presence of seven

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Diagnosis of Frontotemporal Dementia, frontotemporal dementia (bvFTD), associated with behavioural and executive deficits; non-fluent variant primary progressive aphasia (nfPPA), with progressive deficits in speech, grammar, and word output; and semantic variant primary progressive aphasia (svPPA), which is a progressive disorder of se

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,Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models,c and knockout mice have contributed to understanding neurodegenerative processes in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). While initial models for AD and FTLD based on mutations in APP and tau have been generated more than a decade ago, identification of novel genes