Titlebook: MicroRNA and Cancer; Methods and Protocol Wei Wu Book 2018Latest edition Springer Science+Business Media LLC 2018 DNA damage.cancer-immune

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Methods in Molecular Biologyhttp://image.papertrans.cn/m/image/632812.jpg

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https://doi.org/10.1007/978-1-4939-7435-1DNA damage; cancer-immune system interaction; cancer cell resistance; APOBEC gene expression; gene expre

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Detection of Plasma MicroRNA Signature in Osteosarcoma PatientsCirculating microRNAs are increasingly being used as noninvasive prognostic and predictive biomarkers for various types of cancer. We describe a method that uses real-time quantitative PCR (qPCR) for establishing a signature plasma microRNA profile that can distinguish patients with osteosarcoma from healthy control samples.

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Wei WuIncludes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts

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Noncoding RNAs in DNA Damage Response: Opportunities for Cancer Therapeuticsr machinery malfunctioning ultimately manifests in the form of several types of terrible human diseases such as cancers (Hoeijmakers, Nature 411(6835): 366–374, 2001). Noncoding RNAs (ncRNAs) are crucial players of DNA repair machinery in a cell and play a vital role in maintaining genomic stability

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Involvement of miRNAs and Pseudogenes in Cancereudogenes are key players of the noncoding transcripts from the genome, and alteration of their expression levels provides clues for significant biomarkers in pathogenesis of diseases. Especially, miRNAs and pseudogenes have both oncogenic and tumor-suppressive roles in each step of cancer tumorigen

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MicroRNAs Reprogram Tumor Immune Responsegulate expression of genes that are critically involved in both innate and adaptive immune responses. miRNAs have been demonstrated to function as crucial regulators of immune response under both physiological and pathological conditions. Specifically, different miRNAs have been reported to have a r

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