Titlebook: Metals in the Brain; Measurement and Imag Anthony R. White Book 2017 Springer Science+Business Media LLC 2017 Microscopy.fixation artifacts

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Introduction and Overview,brain, from trace levels through to bulk amounts. Methods for measuring levels of metals and imaging metal localization are diverse and often prone to pitfalls associated with a lack of experience in the factors that affect metal detection. These include use of non-physiological metal treatments, fi

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X-Ray Microscopy for Detection of Metals in the Brain,e objects, especially biological tissues, and to resolve features too small for optical microscopes or too thick for electron microscopes, that spurred the development of X-ray microscopes. Their much shorter wavelength means they are less hindered by the diffraction limit which has historically lim

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Probing Biological Trace Metals with Fluorescent Indicators, metal ion concentrations are buffered at very low levels, fluorescent indicators must engage in competitive exchange equilibria with metalloproteins and other endogenous ligands. A meaningful interpretation of the fluorescence response requires therefore a detailed knowledge of the indicator proper

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Microdissection of Alzheimer Brain Tissue for the Determination of Focal Manganese Accumulation,sections for subsequent analysis of metal content. When used in conjunction with inductively coupled plasma mass spectrometry it becomes a powerful method to determine pathogenetically related shifts in the concentration of various cortical transition metals. Key advantages of this approach include

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Size Fractionation of Metal Species from Serum Samples for Studying Element Biodistribution in Alzh with a great potential for studying characteristic abnormalities of metal homeostasis associated with Alzheimer’s disease and other neurodegenerative disorders. For this purpose, serum samples are subjected to protein precipitation under non-denaturing conditions, taking special care for maintainin

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