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Titlebook: Metabolic Reactions in the Nervous System; Abel Lajtha Book 1970 Plenum Press, New York 1970 biochemistry.myelin.nervous system

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Phosphatases,ave at least nonspecific alkaline and acid phosphatases. No observed activity probably means no activity under experimental conditions, not the absence of phosphatases. The nonspecific alkaline and acid phosphatases have been extensively studied. Besides these, many specific phosphatases have been f
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Peptide Hydrolases, the presence in brain of peptides with important physiological properties, the role of these hydrolases in peptide and protein turnover is still obscure. It is well known that brain proteins are in dynamic equilibrium with their environment, with the processes of synthesis matching those of degrada
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Metabolism of Aromatic Amino Acids,substance readily from the blood. It is clear that this ready uptake is due to the functioning of transport mechanisms specific for amino acids. Related aromatic acids and amines are virtually excluded from entry into the brain.
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Sulfur Amino Acids, formed . from methionine in the tissues. Thus it is known that methionine is converted into homocysteine, cystathionine, cysteine, hypotaurine, and taurine. These metabolites are formed in the course of transferring a methyl group to other compounds. The mechanism of demethylation and the subsequen
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Glutamate and Glutamine,rporation of carbon or nitrogen from a variety of precursors in these amino acids is fast and extensive, indicating a rapid turnover of these compounds. The conversion of glutamate to glutamine is thought to be important for the detoxification of ammonia in the brain.
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Glycine: Its Metabolic and Possible Transmitter Roles in Nervous Tissue, amounts in central nervous tissue.. Although glycine is the simplest amino acid from a structural point of view, its intermediary metabolism is far from simple and involves a rather complex series of reactions. However, few of these metabolic steps have been elucidated in the nervous system. Recent
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Deamination of Nucleotides and the Role of their Deamino Forms in Ammonia Formation from Amino Acidn 1953 Muntz. showed that in acetone powder extracts of dog brain the level of ammonia (Am) was increased by a number of nucleotides (AMP, ADP, ATP, NAD, and GMP), the most effective being GMP and NAD. ATP enhanced markedly the deamination of only AMP, with a concomitant increase of IMP. Weil-Malher
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Cerebrosides and Sulfatides,imary amine characterized by 2 hydroxyls (one of them allylic) and 1 amine group. A small amount of dihydrosphingosine occurs also. The fatty acid is of the straight-chain type and may have a hydroxyl group in the 2-position. If the cerebroside contains a hydroxy fatty acid, it is referred to as a h
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Gangliosides,cids and sphingosines and in the number of units in the carbohydrate chain, but only the differences in the latter have been used for the characterization of the gangliosides. All the major gangliosides have in common a neutral carbohydrate moiety, galactosyl-.1→ 3)-.-acetyl-galactosaminyl-.1→ 4)-ga
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