Titlebook: Mechanisms of Steroid Action; G. P. Lewis,M. Ginsburg Textbook 1981Latest edition Macmillan Publishers Limited 1981 pharmaceutical science

adj忧郁的

The structure and function of the progesterone receptor,rone complex then translocates into nuclei and is thought to affect gene expression. The exact mechanism by which the receptor complex acts in nuclei is not yet understood. The purification of the receptor is necessary to gain an understanding of the properties of the hormone-receptor complex and to understand its effects on gene expression.

希望

STEER

,Characterization of ‘native’ and ‘activated’ progesterone and oestrogen receptors from chick oviduc Baulieu ., 1967), it was established that exposure of the tissue to oestradiol . or at 25–30°C . leads to a rapid shift of the receptor-hormone complexes to the nuclear compartment (Jensen ., 1968; Gorski ., 1968). It was also found that, in cell-free systems, this ‘translocation’ of the receptor-o

thwart

Ostrich

Effects of female sex hormones on human endometrium in relation to neoplasia,estrogens are bad and progestins good. This view is based on several types of evidence. Oestrogens are mitogenic, a process that can in some (Ferenczy ., 1979; Martin, 1980) but not all (Finn and Martin, 1970) cases be blocked by progestins. As cell multiplication is an essential, albeit insufficien

immunity

Steroid hormones: blood-borne modulators of nerve cell properties and activity,urred only during the past four decades, and progress in elucidating sites and mechanisms of hormone action has occurred principally during the last 10 years. The initial phase of this investigation (see Beach, 1948; Young 1961 for reviews) established that steroids exert both permanent effects on b

forthy

Steroids and the cells of the immune system,system (see, for example, Dougherty, 1952), the ill-understood complexity of this system has, until recently, made it impracticable to analyse these influences further. In the last few years, however, dramatic advances in cellular immunology and immunobiology and in our understanding of the mechanis

消灭

Mechanism of steroid induced inhibition of arachidonate oxidation,anation for this therapeutic action in terms of their known effects on cellular metabolism. However, the last few years have seen discoveries by several groups which have highlighted a very interesting aspect of steroid action and have culminated in the discovery by us of a ‘second messenger’ of ste

大炮

借喻

Control of androgen metabolism in the peripheral and central structures: physiological implicationsbolise testosterone into 5α-androstan-17β-ol-3-one (dihydrotestosterone, DHT) and subsequently into 5α-androstan-3α,17β-diol (3α-diol) (Wilson and Gloyna, 1970; Robel ., 1971; Schmidt ., 1972; Massa and Martini, 1972, 1974). In the peripheral androgen-responding tissues small amounts of 5α-androstan