Titlebook: Mechanisms of Steroid Action; G. P. Lewis,M. Ginsburg Textbook 1981Latest edition Macmillan Publishers Limited 1981 pharmaceutical science

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,Characterization of ‘native’ and ‘activated’ progesterone and oestrogen receptors from chick oviducrmation’ or ‘activation’ can be obtained in all cases, and that it results in increased binding not only to nuclei but also to DNA and to certain other polyanions (Higgins ., 1973; Milgrom ., 1973), although the changes in observable physico-chemical parameters due to activation vary with the hormon

NEXUS

Effects of female sex hormones on human endometrium in relation to neoplasia,eagle bitches by certain progestins (El Etreby and Neumann, 1980). Another example concerns the natural progestin, progesterone. This steroid decreases the incidence of DMBA-induced rat mammary tumours if given after the carcinogen, as anticipated from the generalisation made above but increases tum

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End-organ metabolism of oestrogens,as been made towards increasing our understanding of the physiologic role of local oestrogen metabolism. We will begin by briefly outlining the various routes of oestrogen formation and metabolism which may take place in target tissues. We will then consider in greater detail the biosynthesis and pr

Obituary

,Steroid hormones—agonists and antagonists, since interdependent regulatory mechanisms seem to condition many hormonal responses (for example, both progestin and androgen binding sites can be induced by oestrogens), it is useful to know whether certain potent drugs classified as agonists of one natural hormone are antagonists of another.

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