Titlebook: Mechanisms of Physical and Emotional Stress; George P. Chrousos,D. Lynn Loriaux,Philip W. Gold Book 1988 The Editor(s) (if applicable) and

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Outshine

Introduction: The Concept of Stress and Its Historical Development. Many definitions and meanings have been ascribed either consciously or unconsciously to the word. Nevertheless, despite a lack of general agreement about its meaning, the term has prevailed because it attempts to address a basic principle of Nature, that of maintenance of balance, equilibrium, or

Prosaic

Sympathoadrenal Medullary System and Stresse complex means of preserving their internal environment, the .. He wrote that “all vital mechanisms, however varied they may be, have only one object, that of preserving the conditions of life in the internal environment.” Modern concepts of stress stem from this tenet.

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Behavioral Pharmacology of Stress: Focus on CNS Corticotropin-Releasing Factoroncept in physiology, psychology and medicine that often eludes precise definition. Hans Selye conceptualized stress as “a nonspecific response to any demand upon the body (usually, but not always, noxious), or anything which causes an alteration of homeostatic processes (1)”. A more modern version

发牢骚

Glucocorticoid Receptors and Behavior: Implications for the Stress Responsecocorticoid levels. Both operating modes are, of course, driven by CNS release of the releasing factor, CRH, in combination with other modulators such as vasopressin and oxytocin (Vale, this volume; Plotsky, this volume; (1)). However, stress-induced release is due to environmental and experiential

Biomarker

CRH Effects on Central Noradrenergic Neurons: Relationship to Stressizes the organism to best respond to a stressful stimulus and ultimately return to a homeostatic state. It is now well established that corticotropin-releasing hormone (CRH) is the primary neurohormone responsible for initiating the endocrine component of the stress response, i.e., release of ACTH f

Amorous

BILK

Corticotropin Releasing Factor Receptors: Characterization and Actions in the Anterior Pituitary Gland behavioral responses to stress, as well as the control of ACTH secretion (1,2). The initial event in the action of CRF in the pituitary gland is its binding to specific plasma membrane receptors, which trigger the formation of intracellular messengers responsible for the activation of ACTH releas

Benign

Vertical

Corticotropin-Releasing Hormone (CRH) Receptors in Braintin (POMC)-derived peptides from the pituitary gland (reviewed in.). More recently, the amino acid sequences of both rat. and human. CRH have been elucidated and were found to be identical to one another but to differ from ovine CRH by seven amino acid residues. In addition to its endocrine role at