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Titlebook: Male-Mediated Developmental Toxicity; Andrew F. Olshan,Donald R. Mattison Book 1994 Plenum Press, New York 1994 behavior.cancer.developmen

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Aneuploidy Tests: Cytogenetic Analyses of Mammalian Male Germ Cellsir father (Sherman et al., 1991). In regard to sex chromosome aneuploidies, all of the XYY trisomies, most of the XO monosomies, and half of the XXY trisomies are considered to be of paternal origin (reviewed by May et al., 1990).
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Male-Mediated Reproductive Toxicity: Effects on the Nervous System of Offspringathers to reproductive and developmental toxicants. In both cases, developmental toxicity studies concentrate on maternal exposures both prior to pregnancy and during gestation. Developmental toxicity due to paternal exposure is rarely considered, even in the cases of recognized reproductive toxicants.
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iologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has
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Strategies for the Use of a Multiple-Endpoint System for Mammalian Germ Cell Mutation Testingh fertility is affected by the test compound. Finally, a multiple-endpoint system allows for flexibility. It is clearly an option to add other assays which may become available in the future and to allow selective use of individual endpoints, according to the requirements of a given experiment.
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