| 书目名称 | Male-Mediated Developmental Toxicity | | 编辑 | Andrew F. Olshan,Donald R. Mattison | | 视频video | | | 丛书名称 | Reproductive Biology | | 图书封面 |  | | 描述 | The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in tox | | 出版日期 | Book 1994 | | 关键词 | behavior; cancer; development; research; toxicity | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4615-1877-8 | | isbn_softcover | 978-1-4613-5764-3 | | isbn_ebook | 978-1-4615-1877-8 | | copyright | Plenum Press, New York 1994 |
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发表于 2025-3-21 17:44:09
