Titlebook: MHC Class-I Loss and Cancer Immune Escape; Federico Garrido Book 2019 Springer Nature Switzerland AG 2019 tumor.immune escape.T lymphocyte

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MHC/HLA Class I Loss in Cancer Cells,LA class-I phenotypes can be observed that are produced by different molecular mechanisms. Experimental and histological evidences are summarized indicating that at the early stages of tumour development there is an enormous variety of tumour clones with different MHC class I expression patterns. Th

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HLA Class-I Expression and Cancer Immunotherapy,py? Are T lymphocytes responsible for tumour rejection and how these responses can be boosted? These questions are discussed in the context of the molecular mechanisms responsible for MHC/HLA class I alterations. If the metastatic tumour cells harbor “irreversible/hard” HLA lesions, they will escape

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Book 2019“Antigen Presenting Molecules” and the “T Lymphocytes”. The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between “self and non self”...Readers will

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Introduction,research have important implications for the new generation of cancer immunotherapy that boosts T cell responses. A historical perspective of major discoveries is presented in this chapter, with the names of the scientists that have made a significant contribution to the enormous progress made in the field of Tumour Immunology.

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0065-2598 cape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the “Antigen Presenting Molecules” and the “T Lymphocytes”. The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgrou

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MHC/HLA Class I Loss in Cancer Cells,the generation of different tumor cell clones with altered MHC class I phenotypes, which could be similar or different from the original tumor clone. The biological and immunological relevance of these observations is discussed. Finally, the interesting phenomenon of metastatic dormancy is analyzed

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Book 2019 stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types

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Federico Garridoden.. Eine ähnliche Aufgabe zur Nachprüfung von Persönlichkeit und Spätschicksal stellte sich . in seinen Studien über eingeschriebene Prostituierte, die 1926 durch die Kata-mnesen . ergänzt wurden ; . untersuchte den geisteskranken Strafgefangenen, . den Landstreicher in seinem Lebensgange.; auf de