| 书目名称 | MHC Class-I Loss and Cancer Immune Escape |
| 编辑 | Federico Garrido |
| 视频video | |
| 概述 | The history of Tumor Immunology.How cancer cells escape the immune response.The new era of Cancer Immunotherapy |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | . ..This book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the “Antigen Presenting Molecules” and the “T Lymphocytes”. The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between “self and non self”...Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answer this question and will explain how cancer cells become invisible to killer T lymphocytes. The loss of the HLA molecules is a major player in this tumor escape mechanism. ..Cancer immunotherapy is aimed at stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types |
| 出版日期 | Book 2019 |
| 关键词 | tumor; immune escape; T lymphocytes; HLA; cancer immunotherapy |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-030-17864-2 |
| isbn_softcover | 978-3-030-17866-6 |
| isbn_ebook | 978-3-030-17864-2Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | Springer Nature Switzerland AG 2019 |
发表于 2025-3-21 19:58:34
