Titlebook: Lymphocyte Immunization Therapy (LIT) in Reproductive Failures; New Horizons Mohan Raut,Mugdha Raut Book 2022 Springer Nature Singapore Pte

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978-981-19-2962-5Springer Nature Singapore Pte Ltd. 2022

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Introduction to Reproductive Immunology and Reproductive Failureconditions, unexplained RPL and unexplained RIF are considered together. This part discusses reproductive immunology and diagnosis of alloimmune factors by immunological tests. The role of lymphocyte immunization therapy (LIT) in these conditions is discussed in the next part.

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Mechanism of Action of LITgh activation of Th2 type of cytokines (anti-inflammatory) leading to a decrease in Th1/Th2 cytokine ratio. These changes are made possible by the role of dendritic cells, which are found in the skin. These mechanisms result in immune tolerance, which prevents miscarriage and implantation failure.

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Case Studieslures. The case studies have discussed diagnostic assessment, LIT procedure and follow up. There is also a detailed discussion about various aspects of LIT. These case studies show that LIT can be beneficial in couples with “unexplained” repeated miscarriages or recurrent IVF failures as these can be due to allo-immune rejection of pregnancy.

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