Titlebook: Leptin; V. Daniel Castracane (Professor Emeritus and Direc Book 2007 Springer-Verlag US 2007 bone.hormone.leptin receptors.metabolism.neur

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Lipodystrophy: The experiment of nature to study leptin,y associated with severe insulin resistance, diabetes mellitus, hyperlipidemia and hepatic steatosis. In women, other features may include acanthosis nigricans, hirsutism and oligomenorrhea. Inherited lipodystrophy first recognized more than on hundred years ago is rare, while acquired lipodystrophy

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Pulsatile and Diurnal Leptin Rhythms,lecules physiological properties. Early research indicated that the molecule exhibited a rhythmic variation akin to that of other hormones. More detailed investigation revealed pulsatility as a key feature of this hormone’s rhythm. The pattern of secretion is very closely tied to that of other hormo

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Leptin in Farm Animals,oendocrine axis in rodents, humans and large domestic animals. The leptin receptor which has been cloned and is a member of the class 1 cytokine family of receptors is found in the brain and pituitary and numerous peripheral tissues. The interaction of leptin in energy metabolism, feed intake regula

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Genetic Disorders Involving Leptin and the Leptin Receptor,osion of interest has to a large extent been driven by the identification of genes responsible for murine obesity syndromes and the novel physiological pathways that have been delineated by these genetic discoveries. Several single gene defects causing severe human obesity have been identified. Many

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Immunoassays for Leptin and Leptin Receptors,tated research leading to the understanding of its role in various physiological and pathophysiological conditions. Immunoassay techniques provide a simple and robust tool for measurement of biomolecules. In this chapter, I describe the principles behind various types of immunoassay methods, feature

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Clinical Applications of Leptin,rine organ. Due primarily to the weight reducing effect of leptin in the . mouse, the initial enthusiasm for leptin clinical investigation was in human obesity. This review will trace the clinical studies from states of leptin deficiency (‘itOb/Ob’, lipodystrophy, hypothalamic amenorrhea), a physiol

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Laura C. Schulz,Eric P. Widmaierle to help planning, executing and controlling project activities and to track and monitor the progress of the project. A major component of a project schedule is a work breakdown structure (WBS). However, the basic critical path method (CPM) schedules, or its often more sophisticated extensions, ar

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Lauren N. Bell,Robert V. Considinerol concepts.Includes two software tutorial overviews to fac.This book presents an integrated approach to monitoring projects in progress using Earned Value and Earned Schedule Management combined with Schedule Risk Analysis. Monitoring and controlling projects involves processes for identifying pot