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Titlebook: Leptin; V. Daniel Castracane (Professor Emeritus and Direc Book 2007 Springer-Verlag US 2007 bone.hormone.leptin receptors.metabolism.neur

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发表于 2025-3-21 16:56:24 | 显示全部楼层 |阅读模式
书目名称Leptin
编辑V. Daniel Castracane (Professor Emeritus and Direc
视频video
概述The timing of this volume is long overdue and it will be the first comprehensive coverage of leptin physiology in the field.Includes supplementary material:
丛书名称Endocrine Updates
图书封面Titlebook: Leptin;  V. Daniel Castracane (Professor Emeritus and Direc Book 2007 Springer-Verlag US 2007 bone.hormone.leptin receptors.metabolism.neur
描述The discovery of leptin by Friedman and his colleagues in 1994 was a seminal discovery in the study of metabolism, providing a new tool to study energy expenditure and appetite regulation. Early studies actively investigated many aspects of metabolism, obesity, and diabetes but it was soon evident that leptin was much more than a metabolic hormone. Today leptin, with almost 11,000 reports in the world‘s literature, is recognized to be important in many areas of physiology with strong suggestions for involvement in clinical conditions as well. Leptin, of course, remains of great interest in obesity and diabetes but other, previously unimagined, areas are now in the realm of leptin physiology. Perhaps leptin and its involvement in many areas of reproductive physiology may be of greatest interest outside of obesity, but other physiological arenas are becoming increasingly involved in the broader understanding of leptin and its pleiotropic functions. These areas include cardiovascular disease, bone physiology, immune regulation, and even cancer and genetics. Clinical trials have suggested other areas of leptin pharmaceutical potential beyond the original promise of obesity management.
出版日期Book 2007
关键词bone; hormone; leptin receptors; metabolism; neuroendocrinology; obesity; physiology; protein; reproduction
版次1
doihttps://doi.org/10.1007/978-0-387-31416-7
isbn_softcover978-1-4419-4065-0
isbn_ebook978-0-387-31416-7Series ISSN 1566-0729
issn_series 1566-0729
copyrightSpringer-Verlag US 2007
The information of publication is updating

书目名称Leptin影响因子(影响力)




书目名称Leptin影响因子(影响力)学科排名




书目名称Leptin网络公开度




书目名称Leptin网络公开度学科排名




书目名称Leptin被引频次




书目名称Leptin被引频次学科排名




书目名称Leptin年度引用




书目名称Leptin年度引用学科排名




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书目名称Leptin读者反馈学科排名




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发表于 2025-3-21 22:47:31 | 显示全部楼层
Leptin Receptors,o be linked with intracellular signaling, and only the longest isoform (ObRb) has full signaling capability. Structure/function analyses of the receptor of the dimer pair reversibly binds a single leptin molecule. Upon binding, signaling cascades are initiated beginning with activation of receptor-a
发表于 2025-3-22 01:53:37 | 显示全部楼层
Leptin and Obesity, tissue depots contribute to greater serum leptin in women than men of equivalent fat mass. Serum leptin circulates in the plasma in association with a binding protein comprised of the extracellular domain of the leptin receptor. The postprandial surge in insulin and glucose stimulate leptin synthes
发表于 2025-3-22 08:15:43 | 显示全部楼层
Leptin and Neuroendocrinology,s one of the most important peripheral signals involved in the variety of neuroendocrine functions, including the regulation of food intake and body weight. Because the hypothalamus is a major site for integration of central and peripheral signals for the maintenance of energy homeostasis and many o
发表于 2025-3-22 12:41:56 | 显示全部楼层
Leptin-Insulin Interrelationships,vels correlate with adipose tissue mass. Via hypothalamic leptin receptors (ObR), it restricts food intake and increases energy expenditure in normal individuals. Leptin is implicated in decreased production and secretion of insulin by the pancreatic beta (β) cell. Insulin, conversely, stimulates le
发表于 2025-3-22 15:07:53 | 显示全部楼层
Leptin and Other Endocrine Systems,arvation is a signal to reduce energy expenditure by limiting thyroid hormone, growth hormone, and gonadal hormone secretion and y increasing cortisol release. The leptin signal is primarily mediated through receptors located within hypothalamic nuclei, although some effects may occur by leptin bind
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发表于 2025-3-22 23:33:32 | 显示全部楼层
Leptin and Bone Central control of bone metabolism by leptin,rvous system, leptin inhibits bone formation via CREB, AP-1 and the molecular clock, while stimulates bone resorption via ATF4. Moreover, leptin also inhibits bone resorption via CART through an unidentified mechanism.
发表于 2025-3-23 02:58:39 | 显示全部楼层
Roles and Regulation of Leptin in Reproduction,tility, and pregnancy. Therefore, second only to its association with obesity, leptin’s role as a reproductive regulator represents the primary research focus of the scientific community to date. A correlation with adipose mass is at least partly responsible for serum leptin concentrations being hig
发表于 2025-3-23 08:11:35 | 显示全部楼层
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