Titlebook: Kinetics and Dynamics of Intravenous Anesthetics; Gerald M. Woerlee Book 1992 Springer Science+Business Media Dordrecht 1992 Infusion.drug

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Physiological Aspects of Drug Kinetics and Dynamics,Before discussing the pharmacokinetic and pharmacodynamic models in current use, it is well worth discussing their physiological basis. This has several advantages.

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Body Weight and Composition,The individuals making up a population vary considerably. Body weight varies with age, and also among individuals of any givien age. The other major difference between individuals in a population is in body composition. A person may be lean, average, muscular or obese.

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Age,The aging process causes extensive changes in body composition and function. These changes affect the kinetics and dynamics of drugs used in anesthesia. This chapter will briefly review the consequences of the most important of these changes on the kinetics and dynamics of intravenous drugs used in anesthesia.

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Obesity,Obesity is an example of an extreme variation of body composition. The physiological changes induced by obesity present the anesthesiologist with many perioperative problems [7], in addition to which these changes also affect the pharmacology of anesthetic drugs.

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Hepatic Dysfunction,The liver is the metabolic powerhouse of the body. Hepatic blood flow is 28% of the cardiac output. It produces nearly all the plasma proteins, and is responsible for the metabolism of most drugs. So hepatic disease can produce extensive changes in body physiology, and these may alter the pharmacology of anesthetic drugs.

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Gerald M. Woerlee M.B., B.S. (W. Aust.), F.F.A.R.C.S. (Lond.)o Galilei, Florentine, aged seventy years ...kneeling before you Most Eminent and Reverend Lord Cardinals ...I abjure, curse, detest the aforesaid errors and heresies.".Galileo Galilei in Rome, 22 June 1633, before the men of the Inquisition..In the small village of Arcetri, on a wooded hillside jus

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