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Titlebook: Kernicterus; David W. McCandless Book 2011 Springer Science+Business Media, LLC 2011

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发表于 2025-3-21 16:22:15 | 显示全部楼层 |阅读模式
书目名称Kernicterus
编辑David W. McCandless
视频video
概述The book is designed to examine the biochemistry and physiology of bilirubin.New concepts relating to the way in which bilirubin is toxic.This volume with examine bilirubin‘s formation, metabolism, tr
丛书名称Contemporary Clinical Neuroscience
图书封面Titlebook: Kernicterus;  David W. McCandless Book 2011 Springer Science+Business Media, LLC 2011
描述Kernicterus (bilirubin encephalopathy) is a highly interesting example of metabolic encephalopathy.It fills all the characteristics of a metabolic encephalopathy in that it can develop rapidly, produces signature signs and symptoms, and is amenable to successful treatment.In the absence of treatment kernicterus can produce devastating sequelae and death.The present volume will examine the biochemistry and physiology of bilirubin as well as its hepatic metabolism and renal excretion.Chapters will elaborate bodily disposition of bilirubin and its neuropathology.Both early treatments and current therapy will be discussed in detail. Phototherapy will be presented, and its efficacy and influence on incidence thoroughly examined.
出版日期Book 2011
版次1
doihttps://doi.org/10.1007/978-1-4419-6555-4
isbn_softcover978-1-61779-701-9
isbn_ebook978-1-4419-6555-4Series ISSN 2627-535X Series E-ISSN 2627-5341
issn_series 2627-535X
copyrightSpringer Science+Business Media, LLC 2011
The information of publication is updating

书目名称Kernicterus影响因子(影响力)




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Biochemistry and Physiology of Bilirubin,of molecules, and Fisher studied hemoglobin. Hemoglobin breaks into heme and globin in its first degradation step. The combination of heme and globin possesses the unique ability to loosely bind oxygen, enabling it to be released to body tissues. Heme bound to iron is termed hemin, which has the che
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Premature Birth,mature (in weeks of age). Definitions based on a gestational age of less than 39 weeks might not be accurate. It is relatively clear that morality rates are closely related to gestational age. For example, the mortality rate in a group of infants weighing between 2.2 and 3.3 lb was about 50%, and in
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Erythroblastosis Fetalis,one. The term erythroblastosis fetalis, applies to Rh isoimmunization resulting in hemolysis, but the term focuses on aspects of the disease which are not always specific or present in each case. This chapter will therefore refer to HDN to describe red blood cell hemolytic anemias. In a very general
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The Gunn Rat Model,C. 1938). The significance of this can hardly be overstated, as nearly all features of this murine model of hyperbilirubinemia correlate exactly with those of the human disorder known as the Crigler–Najjar syndrome. This has permitted extensive and meaningful data to be derived from animal studies.
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Bilirubin and Energy Metabolism,l alterations induced by bilirubin. These studies were conducted by early investigators, and confirmed by later workers. Changes in a multitude of other neurochemical metabolites and compounds have been described, and are the subject of the next chapter. Many of these changes may be secondary to pri
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