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Titlebook: Jaagsiekte Sheep Retrovirus and Lung Cancer; Hung Fan Book 2003 The Editor(s) (if applicable) and The Author(s), under exclusive license t

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Natural History of JSRV in Sheep,ues of sheep affected by both natural and experimental OPA or unaffected in-contact flockmates and never in sheep from unaffected flocks with no history of the tumour. JSRV replicates principally in the epithelial tumour cells, but also establishes a disseminated infection of several lymphoid cell t
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Transformation and Oncogenesis by Jaagsiekte Sheep Retrovirus,il of the transmembrane (TM) protein was shown to be necessary for transformation. Avian DF-1 cells infected with an avian retroviral vector (RCAS) expressing the JSRV envelope protein also undergo tumorigenic transformation. Possible mechanisms of transformation are discussed, and a cooperating rol
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Identification of Hyal2 as the Cell-Surface Receptor for Jaagsiekte Sheep Retrovirus and Ovine Nasall-surface protein that has low hyaluronidase activity and is a member of a large family that includes sperm hyaluronidase (Spam) and serum hyaluronidase (Hyal1). Hyal2 is located in a region of human chromosome 3p21.3 that is often deleted in lung cancer, suggesting that it may be a tumor suppresso
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Enzootic Nasal Adenocarcinoma of Sheep and Goats,uggests that any control strategies, including vaccination, may be appropriate to both diseases. The differences, however, represent a unique resource for delineating the function of individual regions of the virus. It is intriguing that whilst ONAV and CNAV appear to be as different to each other a
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Pathology of Human Bronchioloalveolar Carcinoma and Its Relationship to the Ovine Disease,r lung adenocarcinomas, suggesting that the cellular mechanisms involved are different. Ovine pulmonary adenocarcinoma (OPA) presents with the same symptoms as BAC in humans and is caused by a betaretrovirus — Jaagsiekte sheep retrovirus. Very early on, clinical and histological similarities with hu
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M. De Las Heras,L. González,J. M. Sharpoach may offer a simpler alternative for solving this type of problem in a less limited way, that is, not imposing strong conditions on the defining functions. After the theoretical explanation, many examples are presented in order to demonstrate the efficacy of the method.
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