Titlebook: Iron Acquisition by the Genus Mycobacterium; History, Mechanisms, B. Rowe Byers Book 2013 The Author(s) 2013 Antibiotic Development.Haem Ir

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elds for the potential application of enzymes in a large range of different areas. As more progress in research and application of enzymes has been made the lack of an up-to-date overview of enzyme molecular properties has become more appar­ ent. Therefore, we started the development of an enzyme da

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Mycobacterial Iron Acquisition Mechanisms,ding siderophore production, uptake of ferric-siderophores, production of iron storage proteins, and uptake of heme. Production and function of iron uptake mechanisms is controlled by a regulatory protein. Possible low affinity acquisition through multiple function porins also has been described. In

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Siderocalin Combats Mycobacterial Infections,es, thereby limiting bacterial growth and subsequent colonization by restricting the supply of iron. . synthesizes two siderophores, mycobactin and carboxymycobactin, with the same core structure. Unlike the alkyl side chain of mycobactin, the carboxylate chain of carboxymycobactin imparts water sol

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2191-5407 summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iro

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Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards chieve inhibition of .. .. Although the discussion is focused on biological activity of potential anti-tuberculosis agents, a brief description of the synthetic routes for compounds of interest is given.