书目名称 | Iron Acquisition by the Genus Mycobacterium | 副标题 | History, Mechanisms, | 编辑 | B. Rowe Byers | 视频video | | 概述 | Demonstrates how iron sources can be used by Mycobacterium tuberculosis and other mycobacteria | 丛书名称 | SpringerBriefs in Molecular Science | 图书封面 |  | 描述 | .Iron Acquisition by the Genus .Mycobacterium. summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by .M. tuberculosis. is featured. Because new drugs for .M. tuberculosis. are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.. | 出版日期 | Book 2013 | 关键词 | Antibiotic Development; Haem Iron; Heme Iron; Iron Sources Organisms; M; Tuberculosis; Mycobacterial Dise | 版次 | 1 | doi | https://doi.org/10.1007/978-3-319-00303-0 | isbn_softcover | 978-3-319-00302-3 | isbn_ebook | 978-3-319-00303-0Series ISSN 2191-5407 Series E-ISSN 2191-5415 | issn_series | 2191-5407 | copyright | The Author(s) 2013 |
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