Titlebook: Ion Channels as Targets in Drug Discovery; Gary Stephens,Edward Stevens Book 2024 The Editor(s) (if applicable) and The Author(s), under e

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Ion Channels as Targets in Drug Discovery: Outlook and Perspectives, dominated ion channel drugs but also newer “biologic” agents, such as peptides and larger antibodies. Alongside this, new technological advances, including in drug engineering strategies, structural biology, and related computational modelling techniques, are now starting to make significant contri

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,The Presynaptic α2δ Protein Family and Their Therapeutic Potential,, have been administered particularly in the treatment of neuropathic pain conditions, epilepsy, and restless leg syndrome. Extensive efforts have been and are being made to understand the structure and functions of α.δ proteins and how they interact with synaptic proteins. This is ultimately helpin

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The Contribution of Genetic Sequencing Information to the Identification and Functional Characteriznal genomic information is extremely useful in its own right for patients that are identified as having the mutations, it also has wider implications, when particular K2P channels have a role in physiological processes underlying disease states. As such, modifying the activity of the channels associ

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Nicotinic Receptors of the Neuronal and Non-neuronal Cholinergic Systems as Therapeutic Targets: Opderstanding nAChR function and regulation, the translation of promising preclinical candidates to new therapeutics has been almost totally disappointing. After surveying the diversity of the nAChR family and the opportunities that they present for drug discovery, factors that have limited the succes