Titlebook: Intensive Care Medicine; Annual Update 2006 Jean-Louis Vincent (Head) Conference proceedings 2006 Springer-Verlag New York 2006 Emergency M

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The Role of Toll-like Receptors in Sepsisst to detect host invasion by pathogens, initiate immune responses and form the crucial link between the innate and adaptive immune systems. In general, the immune activation that follows TLR activation is sufficient to combat the wide variety of pathogens that daily invade the human body. However,

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The Emerging Role of RAGE in Sepsis medicine. Sepsis is the systemic inflammatory response to infection frequently associated with hypoperfusion followed by tissue injury and organ failure. Activation of monocytes/macrophages and neutrophils with consecutive release of proinflammatory mediators and activation of the coagulation casca

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HSP90: The Unsung Villain of Sepsis? a wide variety of cellular processes [., .]. Large multidomain proteins are prone to aggregation or to becoming involved in kinetically trapped intermediates; HSP90 is required for a specific set of difficult to fold proteins. When cells are stressed (e.g., because of growth at an unfavorable tempe

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The Role of Extracellular Heat Shock Proteins in Cellular Inflammation and Injury a chance occurrence, a colleague accidentally increased the temperature of one of the incubators in which he kept his specimens, and the following morning Ritossa discovered a new puffing pattern that had not been there on the previous day. Realizing the mistake, Ritossa conducted additional, prope

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Fluid Resuscitation and Immunomodulation in the Critically IIIimately 750,000 cases of sepsis occur each year, at least 225,000 of which are fatal [.]. The incidence of sepsis has increased dramatically in recent decades, largely due to the advancing age of the population, an increased number of invasive procedures being performed and immunosuppressive therapy

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Mitochondrial Dysfunction and Critical Illness Myopathymuscle weakness and paralysis was initially described by Bolton as a critical illness neuropathy [.]. However, research has demonstrated that critical illness polyneuropathy is frequently associated with critical illness myopathy, as well as existing as the sole pathology [., .]. This chapter will f

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