Titlebook: Insights into Receptor Function and New Drug Development Targets; Michael Conn,Claude Kordon,Yves Christen Conference proceedings 2006 Spr

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cAMP- and cGMP-dependent control of lipolysis and lipid mobilization in humans: putative targets foipolysis, the hydrolysis of fat cell triacylglycerols by hormone-sensitive lipase (HSL), promotes the release of NEFA and glycerol by fat cells. HSL regulation is under the potent control of cAMP and the cAMP-dependent protein kinase, protein kinase A (PKA). In human fat cells, adenylyl cyclase acti

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Targeting regulators of G protein signaling (RGS proteins) to enhance agonist specificity,eactivation. Thus they negatively regulate signal transduction mediated by Gi- and Gq-coupled receptors. RGS proteins exhibit both tonic and regulated inhibition of agonist responses, differentially controlling the sensitivity of tissues depending on their post-translational modifications and expres

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Dimeric GPCRs: what did we learn from the metabotropic glutamate receptors?,mounts of data support the idea that GPCRs can form dimers, either homodimers or heterodimers (Bouvier 2001). Such an observation has raised a number of important issues concerning the activation process: what is the stoichiometry required for the dimer activation? Is one agonist per dimer sufficien