Titlebook: Insights into Receptor Function and New Drug Development Targets; Michael Conn,Claude Kordon,Yves Christen Conference proceedings 2006 Spr

厌食症

门闩

needle

歹徒

cAMP- and cGMP-dependent control of lipolysis and lipid mobilization in humans: putative targets fonumber of in vitro studies have clearly established that the repertoire and the level of expression of ARs in human fat cells differ largely according to the anatomical location and the extent of AT, the sex, the age as well as genetic determinants of the subjects. Fat cells from visceral deposits e

adjacent

Central Neuropeptide Receptors Involved in Water Balance: Application to Apelin,horter N-terminal-deleted apelin fragments. This receptor is negatively coupled to adenylate cyclase and internalizes following stimulation with K17F and pE13F. Apelin and its receptor are both widely distributed in the brain and are highly expressed in the supraoptic and paraventricular hypothalami

Explosive

Targeting regulators of G protein signaling (RGS proteins) to enhance agonist specificity,nt tissues and under distinct pathophysiological circumstances. Also, advances in the development of cell-permeable high affinity and selective inhibitors of specific RGS proteins will be needed. Finally, animal models illustrating the physiological functions of RGS proteins will be essential to pre

Neutropenia

Dimeric GPCRs: what did we learn from the metabotropic glutamate receptors?,on to all GPCRs and is responsible for G-protein activation. Using a strategy allowing perfect control of the subunit composition in a mGlu dimer, we showed that a single agonist per dimer is sufficient for activation but that two agonists are required to reach the full activity. Moreover, thanks to

Anemia

harrow

旋转一周

Targets for pituitary tumor therapy,ene (.) inactivation or over-expression support the notion that the trophic environment is permissive for pituitary tumor formation. Understanding the mechanisms underlying pituitary plasticity and their relationship to tumor development will provide subcellular targets for treating both the develop